K3888

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Extract-N-Amp: Sample to PCR in under 15 minutes.

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K3888

Sigma

 

Kenpaullone

≥99%

Synonym:9-Bromo-7,12-dihydro-indolo­[3,2-d]­[1]benzazepin-6(5H)-one, NSC 664704
CAS Number:142273-20-9
Empirical Formula (Hill Notation):C16H11BrN2O
Molecular Weight:327.18
MDL number:MFCD02683595
PubChem Substance ID:24278507

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Description

Biochem/physiol ActionsPotent inhibitor of CDK1/cyclin B (IC50 = 400 nM), CDK2/cyclin A (IC50 = 680 nM), CDK2/cyclin E (IC50 = 7.5 uM) and CDK5/p25 (IC50 = 850 nM).
PackagingStore under argon

Properties

assay≥99%
color yellow
solubilityDMSO: soluble18 mg/mL, clear, yellow
Gene InformationResearch your gene in Your Favorite Gene powered by Ingenuity
human ... CDC2(983)
rat ... Gsk3b(84027)
mouse ... Gsk3b(56637)
storage temp.2-8°C

Safety

Personal Protective Equipmentdust mask type N95 (US), Eyeshields, Gloves
Hazard CodesXi
Risk Statements36/37/38
Safety Statements26-36
WGK Germany3

References

referenceSchultz, C., et al., Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. J. Med. Chem. 42, 2909-2919, (1999)